Over 20 years have passed since the first case of BSE was diagnosed in Spain at the beginning of the century, an event that shaped many of our professional careers. Unfortunately, no treatment exists yet to fight the devastating fate of patients suffering from prion diseases, but since the “mad cow” crisis, formidable breakthroughs have happened in prion science. It is a field that has always embraced the one Health approach: bringing together multidisciplinary scientists to tackle one of the great unsolved challenges in science, to cure prion diseases, which share molecular mechanisms with other protein misfolding disorders of high prevalence in our aging society.